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城市主干道；控制子区；协调控制；关联度；模糊逻辑；智能交通 1

基因回路 1

异戊二烯焦磷酸 1

数值模拟 1

枯草芽孢杆菌 1

柔性材料 1

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Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

《医学前沿（英文）》 2011年 第5卷 第3期   页码 248-253 doi: 10.1007/s11684-011-0149-3

摘要： Chronic allograft vasculopathy (CAV) remains a major obstacle for long-term survival of grafts even though therapeutic strategies have improved considerably in recent years. CAV is characterized by concentric and diffuse neointimal formation, medial apoptosis, infiltration of lymphocyte or inflammatory cells, and deposition of extracellular matrix both in arteries and veins. Recent studies have shown that stem cells derived from the recipient contribute to neointimal formation under the regulation of chemokines and cytokines. Arterial remodeling in allografts eventually causes ischemic graft failure. The pathogenesis is multi-factorial with both immunologic and non-immunological factors being involved. The immunological factors have been discussed extensively in other articles. This review focuses mainly on the arterial remodeling that occurs in 3 layers of vessel walls including intimal injury, accumulation of smooth muscle-like cells in the neointimal, medial smooth muscle cell apoptosis, adventitial fibrosis, and deposition of extracellular matrix.

关键词： transplantation     chronic rejection     neointimal     immunology     arterial remodeling     allograft vasculopathy    

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Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

《医学前沿（英文）》 2017年 第11卷 第3期   页码 403-409 doi: 10.1007/s11684-017-0522-y

摘要：

Tissue factor pathway inhibitor (TFPI) is the main inhibitor of tissue factor-mediated coagulation. TFPI is expressed by endothelial and smooth muscle cells in the vasculature. Endothelium-derived TFPI has been reported to play a regulatory role in arterial thrombosis. However, the role of endogenous TFPI in vascular smooth muscle cells (VSMCs) in thrombosis and vascular disease development has yet to be elucidated. In this TFPIFlox mice crossbred with Sma–Cre mice were utilized to establish TFPI conditional knockout mice and to examine the effects of VSMC-directed TFPI deletion on development, hemostasis, and thrombosis. The mice with deleted TFPI in VSMCs (TFPISma) reproduced viable offspring. Plasma TFPI concentration was reduced 7.2% in the TFPISma mice compared with TFPIFlox littermate controls. Plasma TFPI concentration was also detected in the TFPITie2 (mice deleted TFPI in endothelial cells and cells of hematopoietic origin) mice. Plasma TFPI concentration of the TFPITie2 mice was 80.4% lower (P<0.001) than that of the TFPIFlox mice. No difference in hemostatic measures (PT, APTT, and tail bleeding) was observed between TFPISma and TFPIFlox mice. However, TFPISma mice had increased ferric chloride–induced arterial thrombosis compared with TFPIFlox littermate controls. Taken together, these data indicated that endogenous TFPI from VSMCs inhibited ferric chloride–induced arterial thrombosis without causing hemostatic effects.

关键词： arterial thrombosis     conditional knockout mice     tissue factor pathway inhibitor     vascular smooth muscle cells    

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Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

《化学科学与工程前沿（英文）》 2017年 第11卷 第4期   页码 676-684 doi: 10.1007/s11705-017-1640-4

摘要： Despite limited successes in clinical development, therapeutic cancer vaccines have experienced resurgence in recent years due to an enhanced emphasis upon co-mitigating factors underlying immune response. Specifically, reversing the immune-suppressive effects of the tumor microenvironment, mediated by a variety of cellular and molecular signaling mechanisms, has become fundamental toward enhancing therapeutic efficacy. Therein, our lab has implemented various nano-vaccines based on the lipid-coated calcium phosphate platform for combined immunotherapy, in which antigenic, epitope-associated peptides as well as immune-suppression inhibitors can be co-delivered, often functioning through the same formulation. In probing the mechanism of action of such systems and , an improved effect synergy can be elucidated, inspiring future preclinical efforts and hope for clinical success.

关键词： vaccine     nanoparticle     tumor     immunotherapy     microenvironment    

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Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 408-414 doi: 10.1007/s11684-009-0069-7

摘要： Bone remodeling in orthodontic treatment has been one of the most concerned issues. The purpose of this study was to characterize the changes in bone remodeling on both labial and lingual aspects of the anterior teeth during treatment and retention. Data of 55 extraction cases (41 females and 14 males) were collected at pretreatment, post-treatment, and follow-up stages. Bone thickness on both labial and lingual aspects of the upper and lower incisors were measured at the level of the center of resistance (UC and LC) and that of 3mm apical to the upper and lower incisors’ center of resistance (UAC and LAC). For LC, with the significant lingual movement of point LIR (center of resistance of lower incisor; <0.001), no statistically significant changes in alveolar width on the labial aspect were detected, whereas the reduction of lingual alveolar width was statistically significant (<0.001). In retention, no significant movement of point LIR appeared to occur, while an increase in alveolar width on the lingual aspect was found at this stage. For LAC, the changes in alveolar width as well as the displacement of point LIA (apex of lower incisor) were similar to those of LC. On the maxilla, with the control lingual tipping movement of upper incisor, most of the anterior alveolar changes surrounding the upper incisor were analogous to those of lower incisor. But differently, during treatment, labial bone thickness was increased significantly as the upper incisor moved lingually, and in retention, no statistically significant changes were found on both labial and lingual bone thickness as the upper incisor labially proclined. It was concluded that, with lingual movement of the incisors, bone apposition on the lingual aspect may lag behind the incisor movement. In retention, the lower incisors are in a stable position, with sequential bone apposition being presented on the lingual aspect. However, the upper incisors turn out to be labially relapsed along with the lingual bone resorption and labial bone apposition occurring simultaneously.

关键词： alveolus     remodeling     orthodontics     extraction    

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Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

《机械工程前沿（英文）》 2009年 第4卷 第3期   页码 300-304 doi: 10.1007/s11465-009-0038-5

摘要： To construct the spatial kinetic equation of an arterial tube and obtain its radial natural frequency, a linear-elastic and small deformation condition is assumed. The theoretical analysis is first presented and the finite element method is then used to numerically simulate the spatial kinematics. The results show that the first-order frequency is 15.8 Hz and the obtained exact analytical solutions agree well with numerical solutions, which proves that the theoretical analysis and numerical simulation are both correct.

关键词： spatial kinematics     natural frequency     finite element method    

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Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

《医学前沿（英文）》 2007年 第1卷 第1期   页码 68-73 doi: 10.1007/s11684-007-0014-6

摘要： The association of metabolic syndrome (MS) with arterial compliance in children and adolescents was explored. 337 subjects (188 men and 149 women) aged 6 18 (10.95?3.01) years, out of Beijing Child Metabolic Syndrome Study , were divided into three case groups (one component, two components, three & more components of MS) and one control group based on the Cook s MS definition in children and adolescents. Measurements including anthropometry, blood pressure, fasting plasma glucose and insulin, serum lipid profile were done. Homeostasis model assessment for insulin resistance (HOMA-IR) index was calculated for estimating individual insulin resistance. Arterial compliance was measured using digital pulse wave analyzing method from the pulse trace machine (Micro medical, London), and then the stiffness index (SI) was determined. The mean value of SI in MS group was significant higher than that in control group [(7.69?1.63) vs (6.25?0.86) m/s, <0.01]. With the increase of the clustering of MS components, SI and HOMA-IR were gradually increased. After taking account of gender, age and pubertal development, the partial correlation analysis showed that the amount of components of MS and HOMA-IR were positively correlated with SI (both values were less than 0.05). The arterial compliance of MS group was significantly lowered in children and adolescents, and with the increase of the clustering of MS components, arterial compliance was gradually decreased. It was suggested that arterial compliance assessment in children and adolescents was important for early prevention of cardiovascular diseases.

关键词： compliance assessment     correlation analysis     cardiovascular     clustering     HOMA-IR    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

《医学前沿（英文）》 2020年 第14卷 第6期   页码 726-745 doi: 10.1007/s11684-020-0746-0

摘要： Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblastic leukemia and non-Hodgkin lymphoma and have shown encouraging results in preclinical and clinical studies. However, CAR T cells have achieved minimal success against solid malignancies because of the additional obstacles of their insufficient migration into tumors and poor amplification and persistence, in addition to antigen-negative relapse and an immunosuppressive microenvironment. Various preclinical studies are exploring strategies to overcome the above challenges. Mobilization of endogenous immune cells is also necessary for CAR T cells to obtain their optimal therapeutic effect given the importance of the innate immune responses in the elimination of malignant tumors. In this review, we focus on the recent advances in the engineering of CAR T cell therapies to restore the immune response in solid malignancies, especially with CAR T cells acting as cellular carriers to deliver immunomodulators to tumors to mobilize the endogenous immune response. We also explored the sensitizing effects of conventional treatment approaches, such as chemotherapy and radiotherapy, on CAR T cell therapy. Finally, we discuss the combination of CAR T cells with biomaterials or oncolytic viruses to enhance the anti-tumor outcomes of CAR T cell therapies in solid tumors.

关键词： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city

Mbakisya ONYANGO, Saliha Ammour MERABTI, Joseph OWINO, Ignatius FOMUNUNG, Weidong WU

《结构与土木工程前沿（英文）》 2018年 第12卷 第3期   页码 291-299 doi: 10.1007/s11709-017-0419-5

摘要：

Many transportation agencies lack sufficient funds to maintain and repair roads, which results into increased pavement maintenance cost. Pavement Management System (PMS) has demonstrated to be an essential tool for proper management of infrastructure and proper utilization of available funds. The University of Tennessee at Chattanooga utilized Micropaver software as PMS tool to conduct a pavement management analysis of principal arterials in the City of Chattanooga. The study used the City of Chattanooga pavement database to create the current and future pavement conditions. Maintenance and repair (M&R) planning analysis was also performed in order to determine the most cost-effective treatment and suggest the optimum utilization of funds for the city. An analysis of five budget scenarios was conducted for a five-year plan using the critical pavement condition index (PCI) method (ASTM D6433). Results show that the backlog elimination budget would be the best scenario because it increases the pavement condition and eliminates the backlog of major maintenance and repairs over the five-year period. The unlimited budget seems though ideal, it does not improve pavement condition. Maintaining current condition and limited budget scenarios would increase both the backlog and the total cost of maintenance and repairs over the analysis period.

关键词： PMS     Micropaver     pavement budget     maintenance     rehabilitation    

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一种城市主干道信号动态协调控制方法及其应用 Article

Guo-jiang SHEN,Yong-yao YANG

《信息与电子工程前沿（英文）》 2016年 第17卷 第9期   页码 907-918 doi: 10.1631/FITEE.1500227

摘要： 概要：针对城市主干道的交通流特征，提出了一种新的交通信号协调控制方法。其核心控制算法包括两个模块：控制子区划分模块和信号协调控制模块。本文首先分析了相邻交叉口的路段长度、路段交通密度以及交叉口信号配时参数对相邻交叉口交通关联度的影响，然后设计了基于分层结构的相邻交叉口交通关联度的模糊计算方法和基于关联度的主干道控制子区划分方法。接着提出了一种控制子区协调控制算法，根据一段时间内交通流信息计算控制子区公共信号周期、路段上下行相位差和各路口的绿信比。实际应用表明该控制方法能有效降低主干道交通流平均旅行时间和平均停车率，效果令人满意。

关键词： 城市主干道；控制子区；协调控制；关联度；模糊逻辑；智能交通    

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Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

《医学前沿（英文）》 2020年 第14卷 第1期   页码 60-67 doi: 10.1007/s11684-019-0694-8

摘要： Bromodomain PHD-finger transcription factor (BPTF) is the largest subunit of the nucleosome remodeling factor and plays an important role in chromatin remodeling for gene activation through its association with histone acetylation or methylation. BPTF is also involved in oncogene transcription in diverse progressions of cancers. Despite clinical trials for inhibitors of bromodomain and extra-terminal family proteins in human cancers, no potent and selective inhibitor targeting the BPTF bromodomain has been discovered. In this study, we identified a potential inhibitor, namely, C620-0696, by computational docking modeling to target bromodomain. Results of biolayer interferometry revealed that compound C620-0696 exhibited high binding affinity to the BPTF bromodomain. Moreover, C620-0696 was cytotoxic in BPTF with a high expression of non-small-cell lung cancer (NSCLC) cells. It suppressed the expression of the BPTF target gene c-MYC, which is known as an oncogenic transcriptional regulator in various cancers. C620-0696 also partially inhibited the migration and colony formation of NSCLC cells owing to apoptosis induction and cell cycle blockage. Thus, our study presents an effective strategy to target a bromodomain factor-mediated tumorigenesis in cancers with small molecules, supporting further exploration of the use of these inhibitors in oncology.

关键词： BPTF     small molecule     epigenetics     non-small-cell lung cancer    

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Contemporary coronary artery bypass grafting

null

《医学前沿（英文）》 2014年 第8卷 第4期   页码 395-398 doi: 10.1007/s11684-014-0374-7

摘要：

Current evidence clearly demonstrates that coronary artery bypass grafting (CABG) remains the “gold standard” treatment for most patients with multivessel and left main stem disease. This article summarizes the relevant evidence basis demonstrating that CABG, in comparison to stenting, reduces mortality and subsequent myocardial infarction and the need for repeat revascularization. The article also describes the evidence basis to support the use of more arterial grafts during CABG and the current role of off-pump CABG.

关键词： coronary artery bypass grafting (CABG)     coronary artery disease     left main     arterial grafts     internal mammary artery     off-pump CABG    

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Non-invasive continuous blood pressure monitoring: a review of current applications

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring     Riva-Rocci technique     oscillometric     Pe?áz technique     arterial tonometry     pulse transit time    

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柔性材料对爆炸载荷的缓冲效应研究

于少娟,李永池,刘颢文,孙宇新,胡秀章

《中国工程科学》 2007年 第9卷 第4期   页码 75-78

摘要：

建立了柔性材料桙钢复合壳体在爆炸载荷作用下应力波传播问题的完备方程组；使用有限元方法完成 了对复合壳体在爆炸载荷作用下应力波传播规律的系列数值模拟，并着重讨论了不同炸药层和柔性材料层厚度 对柔性材料与钢交界面载荷的影响。

关键词： 柔性材料     爆炸载荷     载荷改造     数值模拟    

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重构异戊二烯焦磷酸代谢以促进萜类化合物的合成 Article

徐显皓, 吕雪芹, 崔世修, 刘延峰, 夏洪志, 李江华, 堵国成, 李兆丰, Rodrigo Ledesma-Amaro, 陈坚, 刘龙

《工程（英文）》 2023年 第28卷 第9期   页码 166-178 doi: 10.1016/j.eng.2023.03.019

摘要：

萜类化合物是最大的一类天然产物。它们以异戊二烯焦磷酸(IPP)作为基本单元构建而成。使用细胞工厂合成萜类化合物已经引起了极大关注。而迄今为止，IPP的供应不足仍然是高效合成萜类化合物的主要挑战。在本项研究中，我们发现在枯草芽孢杆菌（Bacillus subtilis）中，中心代谢和IPP供应之间的代谢通量分配不平衡阻碍了IPP的积累。因此，我们构建了一系列响应丙酮酸和/或丙二酰辅酶A的双输入多输出（two-input-multi-output, TIMO）基因回路对IPP的代谢途径进行了改造，使IPP的积累增加了将近4倍。随后，设计了一种IPP代谢网络重构策略以提高三种萜类化合物的产量，包括维生素K2 (MK-7, 4.1倍)、番茄红素(9倍)和β-胡萝卜素（0.9倍）。在50-L的生物反应器中，MK-7的产量达到1549.6 mg∙L−1，是迄今为止报道的最高产量。本文提出了一种基于TIMO基因回路的IPP代谢网络重构框架，可用于复杂代谢网络的协同精细调控，从而实现萜类化合物的高效合成。

关键词： 萜类     基因回路     枯草芽孢杆菌     异戊二烯焦磷酸    

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标题 作者 时间 类型 操作

Mechanism of arterial remodeling in chronic allograft vasculopathy

Qichang Zheng, Shanglong Liu, Zifang Song

期刊论文

Endogenous tissue factor pathway inhibitor in vascular smooth muscle cells inhibits arterial thrombosis

null

期刊论文

Nanovaccines for remodeling the suppressive tumor microenvironment: New horizons in cancer immunotherapy

Kai Shi, Matthew Haynes, Leaf Huang

期刊论文

Long-term remodeling of anterior alveolar bone from treatment to retention

Yan LIU MD, Jiuhui JIANG MD, Tianmin XU MD, Haiping ZHANG MD,

期刊论文

Oscillation frequency of simplified arterial tubes

Hui AN, Fan HE, Lingxia XING, Xiaoyang LI

期刊论文

Association of metabolic syndrome with arterial compliance in children and adolescents

ZHANG Li, MI Jie, LI Ming, JIANG Benyu

期刊论文

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

期刊论文

Analysis of cost effective pavement treatment and budget optimization for arterial roads in the city

Mbakisya ONYANGO, Saliha Ammour MERABTI, Joseph OWINO, Ignatius FOMUNUNG, Weidong WU

期刊论文

一种城市主干道信号动态协调控制方法及其应用

Guo-jiang SHEN,Yong-yao YANG

期刊论文

Compound C620-0696, a new potent inhibitor targeting BPTF, the chromatin-remodeling factor in non-small-cell

Jiahui Xu, Qianqian Wang, Elaine Lai Han Leung, Ying Li, Xingxing Fan, Qibiao Wu, Xiaojun Yao, Liang Liu

期刊论文

Contemporary coronary artery bypass grafting

null

期刊论文

Non-invasive continuous blood pressure monitoring: a review of current applications

null

期刊论文

柔性材料对爆炸载荷的缓冲效应研究

于少娟,李永池,刘颢文,孙宇新,胡秀章

期刊论文

重构异戊二烯焦磷酸代谢以促进萜类化合物的合成

徐显皓, 吕雪芹, 崔世修, 刘延峰, 夏洪志, 李江华, 堵国成, 李兆丰, Rodrigo Ledesma-Amaro, 陈坚, 刘龙

期刊论文